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Seneca Therapeutics, Inc. (Seneca) is developing a pipeline of novel cancer agents using the nonpathogenic Seneca Valley Virus isolate 001 (SVV-001). The first product anticipated to be in later stage clinical trials in 2021 is SVV-001 itself. SVV-001 is a targeted immunotherapy that selectively kills cancer cells expressing the SVV-001 receptor, TEM-8, and converts the tumor microenvironment from cold to hot. SVV-001 is expected to synergize with immune checkpoint inhibitors and other cancer agents to significantly benefit more cancer. patients.